Perfluoro Compounds

On June 15, 2011, the TCEQ derived oral reference doses (RfDs) for sixteen PFAS. Later, the TCEQ updated these values to reflect changes in the 2012 revision of the TCEQ Guidelines to Develop Toxicity Factors (RG-442), which were subsequently updated again in 2015. With this 2023 update, the TCEQ is adopting RfDs recently derived by EPA’s IRIS program for perfluorobutyric acid (PFBA) and perfluorohexanoic acid (PFHxA).

This document describes the Systematic Review and Evidence Integration for 16 PFAS. The purpose of the systematic review was to re-evaluate the relevant literature available for these 16 PFAS with the goal of supporting the derivation of relevant oral toxicity factors (reference doses), and when data are available the derivation of inhalation toxicity factors (reference concentrations, effects screening levels) in development support documents (DSDs).

This document is the draft Development Support Document for Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonic Acid (PFOS) and Salts.

This document is the systematic review following the screening performed in the systematic evidence map. All articles that were included in the systematic evidence map were further screened at the full text level by applying a PECO statement which would provide references with appropriate dose response information. This file includes worksheets that show which references were included and excluded. All included references with at least one statistically significant outcome underwent data extraction and were evaluated for study quality.

This document is the systematic map that shows the available literature from the literature search conducted on May 19, 2021. Each article was screened at the title/abstract level by applying the Population, Exposure, Comparator, Outcome (PECO) statement. References that were included, excluded, unclear, or had no abstract are shown in the separate worksheets in the file. Characterization of the types of human, animal, and mechanistic studies available for each of the relevant PFAS compounds was subsequently conducted.