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Chemicals Under Consideration for Toxicity Factor Development

The page contains chemicals under consideration for toxicity factor development by the TCEQ Toxicology Division along with toxicity data requests for those chemicals.

 

Toxicity Data Request

The Toxicology Division is requesting toxicity data relevant for deriving short-term, health-protective comparison value(s) for insoluble dusts that are of inhalable or respirable size. The TCEQ intends to use the comparison value(s) in health effect evaluations of ambient air monitoring samples collected near local emission sources of dust or crustal material, which may include compounds such as calcium sulfate (gypsum) or calcium carbonate (limestone). Comparison value(s) derived in this process will not be used in air permitting or in place of the national ambient air quality standards for particulate matter.

Information relevant to this request includes toxicity data on dusts that are inhalable or respirable and essentially not systemically bioavailable (i.e., insoluble or poorly soluble in lung surfactant). Study designs should include exposure to dusts for which toxicity is a function of the physical presence of the dust itself (e.g., biopersistence in the respiratory tract), rather than a function of toxicologically-active dust chemical constituents (e.g., metals, organics). This request for information also excludes data for compounds for which toxicity is primarily a function of asbestos, quartz, or a constituent for which the TCEQ has previously derived a toxicity value (e.g., crystalline and amorphous/other non-crystalline forms of silica, various metals). Preferred toxicity data should come from studies that

  • are well-conducted; evaluate adverse effects that are definitively attributable to dust exposure;
  • accurately measure exposure concentrations and durations; and
  • evaluate either single or repeated acute (e.g., typically 1-8 hour) exposures.

Please submit any relevant scientific data or publications by January 31, 2019.

Procedure for Data Submission

e-mail: tox@tceq.texas.gov or by mail (must be received at the TCEQ no later than 1/31/19) to:

Regular mail:

Toxicology Division, MC 168

Texas Commission on Environmental Quality

P.O. Box 13087

Austin, TX 78711-3087

Mail delivery services:

Toxicology Division, MC 168

Texas Commission on Environmental Quality

12100 Park 35 Circle, Bldg. F

Austin, TX 78753

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Call:
877-992-8370 (toll free) or 512-239-1795

E-mail: tox@tceq.texas.gov

Write: Texas Commission on Environmental Quality

Toxicology Division, MC 168

P.O. Box 13087

Austin, TX 78711-3087

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